Folklore Clinical Variant Interpretation MCP
Free, read-only bioinformatics MCP for GRCh38 germline variant interpretation, gene-disease evidence and literature. No API key. Results require qualified professional review.
Free, read-only bioinformatics MCP for GRCh38 germline variant interpretation, gene-disease evidence and literature. No API key. Results require qualified professional review.
Features
Category
Connect to the hosted server using Streamable HTTP: https://api.helena.bio/folklore/v1/mcp No account or API key is required. Scientific tools: search_variant_evidence, search_variant_literature, get_publication_details, search_literature_corpus, get_gene_disease_associations, search_disease_genes. The separate support_helena helper is opt-in and does not change scientific results. Supports one public GRCh38 germline SNV or simple indel smaller than 50 bp, ClinGen gene-disease evidence and scientific literature. Preserve provenance, ambiguity and limitations. Qualified professional review is required; this is not patient diagnosis or treatment advice. Do not submit patient records, family information or private case data. No VCF uploads, FASTQ/BAM processing or batch analysis. Publisher: Helena Bioinformatics. Public MCP protocol adapter: Apache-2.0. Official logo: https://folklore.helena.bio/images/logos/folklore.png Full setup: https://folklore.helena.bio/integrations/mcp
search_variant_evidence
Interpret one supported GRCh38 germline variant with ACMG/AMP evidence and provenance.
search_variant_literature
Retrieve literature linked to one supported public germline variant.
get_publication_details
Retrieve the public bibliographic record for one PMID.
search_literature_corpus
Search the public scientific literature corpus by question or identifiers.
get_gene_disease_associations
Retrieve ClinGen gene-disease validity assertions for a gene.
search_disease_genes
Find genes associated with a disease from ClinGen assertions.
support_helena
Opt-in information about supporting Helena public infrastructure; no scientific effect.
folklore-variant-evidence-view
Optional read-only Variant Evidence MCP App: ui://folklore/variant-evidence/v1.html
classify_germline_variant
Resolve one public germline variant and review automated classification and evidence.
review_vus_evidence
Review VUS evidence without treating uncertainty as a pathogenic or benign conclusion.
explain_acmg_classification
Explain returned ACMG/AMP criteria and limitations.
verify_variant_identity
Verify one public variant identity and preserve ambiguity.
compare_variant_literature
Compare variant evidence with related literature while separating association from pathogenicity.
{"mcpServers":{"folklore":{"url":"https://api.helena.bio/folklore/v1/mcp"}}}Memory
Knowledge graph-based persistent memory system
PostgreSQL
Read-only database access with schema inspection
Sqlite
Database interaction and business intelligence capabilities
Supabase
Interact with Supabase: Create tables, query data, deploy edge functions, manage auth, storage, and more.
Qdrant
Implement semantic memory layer on top of the Qdrant vector search engine
MySQL
MySQL database integration with configurable access controls, schema inspection, and comprehensive security guidelines.